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Deutsche Bahn is a worldwide leader in railway services with its network of railway lines that transport passengers and freight across Germany and Europe. At the core of the DB Group is the Deutsche Bahn Group, which owns...

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The website of Splinter, a microframework based on Sinatra. - ebruch

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icey

Blogspam?

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kaddar

wow! what a buzz! i like the idea!

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brlewis

If you make a really nice blog engine that no one knows about, you might get

someone to make the next major blogging platform on top of it.

Deubiquitinating enzyme 1 (DUB1) deficiency in mice leads to a prenatal lethal anemia.

DUB1 is a member of the deubiquitinating enzyme family and specifically catalyzes the removal of the ubiquitin chain from specific substrates. Although the role of DUB1 in the ubiquitin-proteasome system (UPS) has been studied extensively, its biological function is still largely unknown. To characterize DUB1 function, we generated mice with a knockdown of DUB1 function by using a specific DUB1-targeting ribozyme (DUB1-Rz). We found a critical role of DUB1 in the development and maintenance of erythropoiesis. Microcytic anemia was evident at birth and progressively became more severe throughout the lifespan in